Journal: Frontiers in Immunology

Article Title: The HLA class I immunopeptidomes of AAV capsid proteins

doi: 10.3389/fimmu.2023.1212136

Figure Lengend Snippet: More than 60% of the AAV HLA class I peptides are contained within HLA class II clusters. (A) Representation of an HLA class I peptide contained within an HLA class II cluster. In this example we show the immunogenic epitope IPQYGYLTL fully contained within a cluster of HLA class II that have the similar sequences. (B) Venn diagrams showing the number of peptides that are unique and contained between HLA class II and HLA class I for each of the immunopeptidomes. (C) Heatmap comparison of the HLA class I and HLA class II immunopeptidomes. The heatmaps represent the sum of all the peptides that were displayed among the different cohorts in this study and in Brito-Sierra et al., 2022 . For ease of representation, the HLA class II heatmaps are shown in log2 scale.

Article Snippet: Data representation in bar graphs and heatmaps was performed in GraphPad Prism 9, as well as t-test statistical analysis.

Techniques: Comparison